Gene information
Official symbol IL6R
Official full name interleukin 6 receptor
Gene type protein-coding gene
Chromosome1q21.3
Alias symbolCD126
Gene familyCD molecules; Immunoglobulin like domain containing; Interleukin receptors
Resources
Entrez Gene 3570
HGNC HGNC:6019
Ensembl ENSG00000160712
Vega OTTHUMG00000036073
UCSC uc001fez.2
GO terms: 101 records
GO Description Category LogP Number of genes Detail
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001816 cytokine production GO Biological Processes -9.14810130 8 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002251 organ or tissue specific immune response GO Biological Processes -5.08329154 5 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002263 cell activation involved in immune response GO Biological Processes -10.3401505 18 More
GO:0002285 lymphocyte activation involved in immune response GO Biological Processes -7.04246662 12 More
GO:0002286 T cell activation involved in immune response GO Biological Processes -5.33688125 8 More
GO:0002287 alpha-beta T cell activation involved in immune response GO Biological Processes -5.32260704 6 More
GO:0002292 T cell differentiation involved in immune response GO Biological Processes -5.02945267 6 More
GO:0002293 alpha-beta T cell differentiation involved in immune response GO Biological Processes -5.32260704 6 More
GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO Biological Processes -5.40213264 6 More
GO:0002360 T cell lineage commitment GO Biological Processes -3.67847337 4 More
GO:0002366 leukocyte activation involved in immune response GO Biological Processes -10.4998832 18 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002548 monocyte chemotaxis GO Biological Processes -10.9439631 11 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0004896 cytokine receptor activity GO Molecular Functions -9.30297759 21 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005138 interleukin-6 receptor binding GO Molecular Functions -7.06549339 4 More
GO:0005896 interleukin-6 receptor complex GO Cellular Components -6.44865956 3 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010533 regulation of activation of Janus kinase activity GO Biological Processes -5.46227840 4 More
GO:0010536 positive regulation of activation of Janus kinase activity GO Biological Processes -6.00954872 4 More
GO:0010573 vascular endothelial growth factor production GO Biological Processes -10.4763648 6 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030098 lymphocyte differentiation GO Biological Processes -7.22308617 17 More
GO:0030217 T cell differentiation GO Biological Processes -5.22709721 11 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031016 pancreas development GO Biological Processes -6.43498850 15 More
GO:0031018 endocrine pancreas development GO Biological Processes -4.66781085 9 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035270 endocrine system development GO Biological Processes -10.2307745 25 More
GO:0035710 CD4-positive, alpha-beta T cell activation GO Biological Processes -4.53716649 6 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042093 T-helper cell differentiation GO Biological Processes -5.40213264 6 More
GO:0042110 T cell activation GO Biological Processes -7.78997285 18 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.8380655 19 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043367 CD4-positive, alpha-beta T cell differentiation GO Biological Processes -4.83197184 6 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045165 cell fate commitment GO Biological Processes -15.5778047 44 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045667 regulation of osteoblast differentiation GO Biological Processes -10.7517956 27 More
GO:0045669 positive regulation of osteoblast differentiation GO Biological Processes -8.83631876 18 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0046631 alpha-beta T cell activation GO Biological Processes -4.13140497 7 More
GO:0046632 alpha-beta T cell differentiation GO Biological Processes -3.95887136 6 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050829 defense response to Gram-negative bacterium GO Biological Processes -15.0142277 17 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0070102 interleukin-6-mediated signaling pathway GO Biological Processes -3.91273904 3 More
GO:0070741 response to interleukin-6 GO Biological Processes -9.27147512 9 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071354 cellular response to interleukin-6 GO Biological Processes -8.31494447 8 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0072124 regulation of glomerular mesangial cell proliferation GO Biological Processes -6.00516542 6 More
GO:0072538 T-helper 17 type immune response GO Biological Processes -3.91273904 3 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097191 extrinsic apoptotic signaling pathway GO Biological Processes -9.74858067 13 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:1901722 regulation of cell proliferation involved in kidney development GO Biological Processes -6.22004109 7 More
GO:1903131 mononuclear cell differentiation GO Biological Processes -9.35861236 21 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 11 records
KEGG Description Category LogP Number of genes Detail
hsa01521 EGFR tyrosine kinase inhibitor resistance KEGG Pathway -6.02704244 9 More
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04640 Hematopoietic cell lineage KEGG Pathway -11.4657972 15 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
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Related drugs: 9 records
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
IL6R transcriptomics acute myocardial infarction[diagnosis] acute myocardial infarction Anderson DR et al. Cytokine. 2013
interleukin-6 receptor subunit alpha proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ueda K et al. Am Heart J. 1999
interleukin-6 receptor subunit alpha proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Kimura T et al. Eur J Endocrinol. 2000
interleukin-6 receptor subunit alpha proteomics euthyroid sick syndrome[prognosis (bad)] acute ST elevation myocardial infarction Kimura T et al. Eur J Endocrinol. 2000
interleukin-6 receptor subunit alpha proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kanda T et al. Cardiology. 2000
interleukin-6 receptor subunit alpha proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Anderson DR et al. Cytokine. 2013
interleukin-6 receptor subunit alpha proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Ritschel VN et al. J Am Heart Assoc. 2016
interleukin-6 receptor subunit alpha proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Ritschel VN et al. J Am Heart Assoc. 2016
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